|Year : 2021 | Volume
| Issue : 6 | Page : 221-226
Manifestations and risk factors of COVID-19 and mucormycosis: A mini-review
Jugal Sutradhar1, Bapi Ray Sarkar2
1 Institute of Pharmacy, Harishchandra PG College, Bawan Beegha, Varanasi 221002, India
2 Department of Pharmaceutical Technology, University of North Bengal, Raja Rammohunpur, Darjeeling, West Bengal 734013, India
|Date of Submission||03-Jul-2021|
|Date of Decision||04-Nov-2021|
|Date of Acceptance||06-Nov-2021|
|Date of Web Publication||30-Nov-2021|
Institute of Pharmacy, Harishchandra PG College, Bawan Beegha, Varanasi 221002
Source of Support: None, Conflict of Interest: None
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has become a pandemic disease. It also increases the risk of co-infections. Mucormycosis is a severe fungal infectious disease and its causative agent, mucormycetes, belongs to an opportunist fungus Mucoraceae family. Mucormycosis in COVID-19 patients with mucormycosis presents an additional challenge worldwide. Mucormycosis shares certain risk factors and signs and symptoms with COVID-19. In this review, we summarize manifestations and risk factors of mucormycosis and COVID-19.
Keywords: COVID-19; Mucormycosis; Manifestations; Risk factors
|How to cite this article:|
Sutradhar J, Sarkar BR. Manifestations and risk factors of COVID-19 and mucormycosis: A mini-review. J Acute Dis 2021;10:221-6
| 1. Introduction|| |
Mucormycosis, a rare severe fungal infection, shows a high risk in immunocompromised patients, particularly patients with uncontrolled diabetes mellitus, iron overload, major trauma, and patients who are treated with high-dose of corticosteroid, and patients with large open wounds contaminated by Mucorales,. Normally elevated levels of inflammatory cytokines have been observed in COVID-19 patients. The immune response dysregulation is associated with coronavirus disease, with reduced T-lymphocytes (CD4+T and CD8+T) cells, and also may alter the innate immunity. That may permit secondary fungal infections,. In this review, we summarized highly destructive fungal infection (mucormycosis) with globally affected COVID-19 disease.
| 2. Manifestations of COVID-19 and mucormycosis|| |
The COVID-19, a global pandemic infectious disease, is a life-threatening respiratory disease that can affect near all organs of our body and is also associated with venous thrombosis, strokes, renal failure, cardiomyopathy, systemic vasculitis, and coronary,. The common symptoms in COVID-19 disease are fever, nasal congestion, sore throat, shortness of breath, fatigue, muscles pain, headache, weight loss, gastric disturbances, and rashes on the skin. These infection symptoms may arise in the human body between 2 to 14 days. Some patients’ chest CT scans may show bilateral ground-glass opacity changes and lymphopenia, and the liver and heart specimens are likely to present some interstitial mononuclear inflammatory infiltrates. Otherwise, asymptomatic or mild symptoms also were noted in a large number of populations,. In the beginning, the viral reproduction numbers could be higher within the lower position of the respiratory tract, and infected cells are released causing inflammation signal molecules. Finally, pulmonary edema can be loaded in the alveolar spaces by hyaline membrane formation.
Mucormycosis or zygomycosis, a fungal infectious disease, is highly severe, often acute. This disease is caused by ubiquitous and opportunist fungi belonging to the Mucoraceae family. Normally the mucormycetes are found in dust and soil in the form of spores. These spores can be inhaled by a humans through the upper respiratory tract and finally spread toward the sinuses and invade into the brain, causing rhinocerebral mucormycosis and symptoms like fever, one side facial swelling, headache, sinus congestion, and black lesions outside the face or inside the mouth. While spores infection incorporates into the digestive system, it will induce gastrointestinal mucormycosis and symptoms such as abdominal pain, gastrointestinal bleeding, nausea, and vomiting. If infection occurs in dermal deep lacerations, it can cause cutaneous or disseminated mucormycosis, and the symptoms are the same with other types,. Chakrabarti et al. divided mucormycosis into 3 clinical stages as stage I (signs and symptoms into the sino-nasal area), stage-II (sino-nasal area and sino-orbital infection), and stage III (intracranial involvement). Sugar also reported an uncommon presentation of renal infection. Initial computed tomography (CT-scan) of lung mucormycosis, the most common radiological pattern is a halo sign and then may deteriorate into mass/nodule. The standard roentgenograms and CT scans often reveal distinct degrees of swelling (soft-tissue) and, finally, bone damage that is typical of progressive mucormycosis,.
Signs and symptoms of COVID-19 disease are similar to fungal diseases such as fever, shortness of breathing, and cough. Earlier laboratory testing is important to determine the COVID-19 and fungal infection. Patients can simultaneously suffer from fungal infection and COVID-19. Some authors have reported cases of invasive mucormycosis patients with COVID-19. Severe COVID- 19 patients in an ICU (intensive care unit) are susceptible to fungal and viral infection. Saldanha et al. reported a case of a 32- year-old lady who reported a 6 months history of uncontrolled diabetes and presented with complications in the left eye as well as facial pain. This patient was detected COVID-19 infection, and finally, histopathological examination showed mucormycosis. Revannavar et al. reported a middle-aged woman newly detected diabetes, and she had a complicated fever and left-side facial pain. Initially, she was tested positive for COVID-19 disease, and then histopathological examination confirmed mucormycosis infection. Khatri et al. reported a case of a 68-year-old man who had undergone a heart transplant. Two months later, cough, fever, diarrhea, and mucormycosis occurred after COVID-19 [Table 1].
|Table 1: Clinical profile, managements and outcomes of COVID-19 with mucormycosis.|
Click here to view
| 3. Risk factor of COVID-19 disease and mucormycosis|| |
In recent decades, mucormycosis has increased due to the rising number of immunocompromised patients worldwide (mostly in developing countries). The highest number of cases was observed in India because of uncontrolled diabetes mellitus and trauma patients. Rhinocerebral type of mucormycosis disease mainly occurs in diabetic ketoacidosis (two-thirds of the cases),, and pulmonary mucormycosis most appear in patients who are already suffering from hematological malignancies. Other long-proved risk factors of mucormycosis include AIDS, hematological disorders, liver cirrhosis, organ transplant, and high doses of steroids. Uncontrolled diabetes ketoacidosis patients with iron overload take a higher risk of fungal infection, so do mucormycosis patients. Most occasional cases of mucormycosis are reported in hospital lines, tornados, building construction, wooden tongue depressors, and adhesive bandages.
At the beginning of the COVID-19 pandemic, there was a heated discussion on whether a person with immunosuppressants is more vulnerable to COVID-19 infection,. The most notable risk factors for COVID-19 are comorbidities and advanced age. On the other hand, diabetes is one of the major risks at play. Other common factors include cardiovascular disease, malignancy, hypertension, chronic respiratory diseases, kidney and liver diseases, and local immunodeficiencies. Other possible complication factors are acute kidney injury, thromboembolism, and coagulation disease,,.
The risk factors of both mucormycosis and COVID-19 are co-morbidities, uncontrolled diabetes mellitus, and corticosteroids drugs. The use of glucocorticoids produces various complex effects qualitative as well as quantitative immunosuppressive that influences cellular immunodeficiency and increases host possibilities to invasive fungal infection. The extensive use of corticosteroids has increased glucose homeostasis. That may lead patients to mucormycosis. Corticosteroid drug use is a major risk factor for mycoses and mucormycosis. A multicenter retrospective study in India from September to December in 2020, included 187 patients who suffered COVID-19 associated mucormycosis disease, and also observed diabetes mellitus and improper steroids use are quite common in these patients. Seriously ill COVID-19 patients, especially those admitted into intensive care units and also in ventilation, or who had been hospitalized for longer periods, risk suffering fungal infection. Monte Junior et al. represented a case of an 86-year-old male patient who suffered from fever, cough, acute diarrhea, and dyspnea, was admitted to an emergency room, and then tested positive for COVID-19 infection. This patient was treated with hydrocortisone, azithromycin, ceftriaxone, oseltamivir, and management with mechanical ventilation. After that, the patient blood report showed severe anemia (reduced hemoglobin level), thus, he was given 3 units of blood and omeprazole. According to the esophagogastroduodenoscopy report, two giant gastric ulcers and a deep hemorrhagic base were found. This patient died after one week and the pathological report showed mucormycosis. Zurl et al. reported a case of 53-year-old male presented with obesity, depression, and myelodysplastic syndrome. Further, observation discovered other symptoms like fever, dysosmia, parageusia, soreness. Then polymerase chain reaction test was conducted, and the result confirmed COVID-19 infection. Therefore, treatment with high-dose of glucocorticoid and tocilizumab was initiated. Finally, the patient died after 24 days and a postmortem report was shown pulmonary mucormycosis. In a case report by Maini et al., a 38-year-old male (no history of diabetes) hospitalized COVID-19 patient case was represented. This patient was treated with remdesivir IV injection. Dexamethasone injection was started after 11 days and continued for 12 days. After 18 days, the patient complained of pain, and his left eye showed chemosis. Consequently, diagnosis with mucormycosis. Nehara et al. reported a case series of mucormycosis in a COVID-19 infection patient during his/her course of treatment. Recently, 101 cases of COVID-19 with mucormycosis disease have been reported, of which 82 cases were from India and 19 from other countries, until May 13, 2021.
| 4. Conclusion|| |
As COVID-19 disease has swept over the whole world and is making a recurrence, threats from the fungal co-infection disease such as mucormycosis become higher. Most of the signs and symptoms are same for both COVID-19 and mucormycosis diseases like cough, shortness of breathing, and fever. Early detection can reduce the severity as well as the mortality rate of the two diseases. On top of this, most of the risk factors are similar to both diseases. Management of COVID-19 by steroids, monoclonal antibodies, broad-spectrum antibiotics may develop mucormycosis. The recent paper provides new information on COVID-19 and mucormycosis disease this will help to motivate researchers and healthcare professionals.
Conflict of interest statement
The authors report no conflict of interest.
B.R.S.: contributed the supervision, validation, visualization, review, and editing; J.S.: contributed towards the writing-original manuscript, literature searching and editing.
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