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Biomarkers in acute brain trauma: A narrative review
GA Quinones-Ossa1, H Padilla-Zambrano2, R Pal3, A Ghosh4, LR Moscote-Salazar5, VA Kiran Kumar6, A Agrawal6
1 Faculty of medicine, El Bosque University, Bogota, Colombia
2 Faculty of Medicine, University of Cartagena, Cartagena de Indias, Colombia
3 Department of Community Medicine, MGM Medical College and LSK Hospital, Kishanganj-855107, India
4 Department of Biochemistry, Medical College, 88, College Street, Kolkata-700073, India
5 Red Latino, Organización Latinoamericana de Trauma y cuidado Neurointensivo, Bogota, Colombia
6 Department of Neurosurgery, Narayana Medical College, Nellore, Andhra Pradesh, India
Correspondence Address:
Dr. A Agrawal
Professor of Neurosurgery, Department of Neurosurgery, Narayana Medical College Hospital, Chinthareddypalem, Nellore-524003, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None  | 5 |
DOI: 10.4103/2221-6189.250370
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Biomarkers have been used to diagnose, prognose, evaluate, and identify the severity and outcomes in traumatic brain injury (TBI) patients. This study explored if it is possible to predict the outcome of TBI patients by estimating the biomarkers in cerebrospinal fluid and serum. We searched data bases and literature about biomarkers, and found forty epidemiologic studies from 92 potentially relevant articles. However, limited data are available about postanoxic encephalopathy. It showed that presently, neurofilament, S100B, glial fibrillary acidic protein, and ubiquitin carboxyl terminal hydrolase-L1 seemed to have the best potential as diagnostic biomarkers for distinguishing focal and diffuse injury, whereas C-Tau, neuron-specific enolase, S100B, glial fibrillary acidic protein, and spectrin breakdown products appear to be candidates for reflective biomarkers of TBI. Point-of-care biomarkers are needed in TBI which is one of the most important additional risk factors in road traffic injuries. In a holistic approach, more researches about biomarkers of TBI are required. These biomarkers are very useful for treatment of patients with TBI. |
